Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of anaplastic lymphoma kinase in pediatric cancers.

Cancer science - 1 Oct 2017

Takita Junko

Abstract excerpt

The anaplastic lymphoma kinase (ALK) gene was initially identified as a fusion partner of the nucleophosmin gene in anaplastic large-cell lymphoma with t(2;5)(p23;q35) translocation, and then described with different genetic abnormalities in a number of tumors. Although ALK is known to be involved in the pathogenesis of neuroblastoma through activating mutations or gene amplification, its role in the pathogenesis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaplastic Lymphoma Kinase
Share to Gene Amplification
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large-Cell, Anaplastic

Share to Neuroblastoma

Share to Receptor Protein-Tyrosine Kinases

Share to Sarcoma, Ewing

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28756644
DOI: 10.1111/cas.13333
PMCID: PMC5623752

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of anaplastic lymphoma kinase in pediatric cancers.PMID 28756644Read ↗

Anaplastic Lymphoma Kinase as a Cancer Target in Pediatric Malignancies.Semantic proximity Read ↗

Potential therapies for anaplastic lymphoma kinase-driven tumors in children: progress to date.Semantic proximity Read ↗

Anaplastic lymphoma kinase in human cancer.Semantic proximity Read ↗

Anaplastic lymphoma kinase: signalling in development and diseaseSemantic proximity Read ↗

ALK in Neuroblastoma: Biological and Therapeutic ImplicationsSemantic proximity Read ↗

Oncogenic mutations of ALK in neuroblastoma.Semantic proximity Read ↗

Oncogenic anaplastic lymphoma kinase (ALK) mutation in neuroblastomas and other pediatric tumors.Semantic proximity Read ↗

Targeting anaplastic lymphoma kinase in neuroblastomaSemantic proximity Read ↗

Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many FacesSemantic proximity Read ↗

Anaplastic lymphoma kinase: Role in cancer and therapy perspective.Semantic proximity Read ↗

Anaplastic lymphoma kinase rearrangements in non-small-cell lung cancer: novel applications in diagnostics and treatment.Semantic proximity Read ↗

Anaplastic Lymphoma Kinase as a Therapeutic Target in Anaplastic Large Cell Lymphoma, Non-Small Cell Lung Cancer and NeuroblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.