Article
Evidence for ORC-dependent repression of budding yeast genes induced by starvation and other stresses.
FEMS yeast research - 1 Aug 2006
Ramachandran Lakshmi, Burhans Debra T, Laun Peter, Wang Jianxin, Liang Ping, Weinberger Martin, Wissing Silke, Jarolim Stefanie, Suter Bernhard, Madeo Frank, Breitenbach Michael, Burhans William C
Abstract excerpt
The highly conserved origin recognition complex (ORC) is required for repressing genes in the silent mating type loci of budding yeast. Here we report that at a non-permissive temperature, the temperature-sensitive orc2-1 mutation induces the expression of more than 500 genes, the majority of which are also induced during starvation of wild-type cells. Many genes induced by starvation or by the orc2-1 mutation...
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