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Article

G protein-coupled receptors: mutations and endocrine diseases.

Nature reviews. Endocrinology - 1 Jun 2011

Vassart Gilbert, Costagliola Sabine

Abstract excerpt

Over the past 20 years, naturally occurring mutations that affect G protein-coupled receptors (GPCRs) have been identified, mainly in patients with endocrine diseases. The study of loss-of-function or gain-of-function mutations has contributed to our understanding of the pathophysiology of several diseases with classic hypophenotypes or hyperphenotypes of the target endocrine organs, respectively. Simultaneously,...

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PMID: 21301490
DOI: 10.1038/nrendo.2011.20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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