Interallelic class switch recombination can reverse allelic exclusion and allow trans-complementation of an IgH locus switching defect.

Abstract excerpt

The predominant path of immunoglobulin class switch recombination follows the paradigm of intra-chromosomal deletion enabling expression of another heavy chain instead of micro and delta. This was, however, challenged by observations of inter-allelic class switch recombination in rabbit or mouse IgG3- or IgA-producing B cells. Assuming that the conditions of inter-chromosomal exchange are likely present at any...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to B-Lymphocytes
• Share to Enzyme-Linked Immunosorbent Assay