Article
Interallelic class switch recombination can reverse allelic exclusion and allow trans-complementation of an IgH locus switching defect.
European journal of immunology - 1 Aug 2006
Dougier Hei-Lanne, Reynaud Stéphane, Pinaud Eric, Carrion Claire, Delpy Laurent, Cogné Michel
Abstract excerpt
The predominant path of immunoglobulin class switch recombination follows the paradigm of intra-chromosomal deletion enabling expression of another heavy chain instead of micro and delta. This was, however, challenged by observations of inter-allelic class switch recombination in rabbit or mouse IgG3- or IgA-producing B cells. Assuming that the conditions of inter-chromosomal exchange are likely present at any...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- Gene Expression Regulation
- Immunoglobulin Class Switching
- Immunoglobulin Heavy Chains
- Immunoglobulin Switch Region
- Lipopolysaccharides