Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function.

Autophagy - 1 Apr 2005

Furuya Norihiko, Yu Jie, Byfield Maya, Pattingre Sophie, Levine Beth

Abstract excerpt

Atg6/Beclin 1 is an evolutionarily conserved protein family that has been shown to function in vacuolar protein sorting (VPS) in yeast; in autophagy in yeast, Drosophila, Dictyostelium, C.elegans, and mammals; and in tumor suppression in mice. Atg6/Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III phosphatidylinositol 3'-kinase (PI3K)/Vps34. However, nothing is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Beclin-1

Share to Cathepsin D

Share to Genes, Tumor Suppressor

Share to Neoplasm Transplantation

Share to Transplantation, Heterologous

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 16874027
DOI: 10.4161/auto.1.1.1542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function.PMID 16874027Read ↗

The Biological Role and Clinical Significance of BECLIN-1 in CancerSemantic proximity Read ↗

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.Semantic proximity Read ↗

A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolutionSemantic proximity Read ↗

Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination CascadesSemantic proximity Read ↗

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherinSemantic proximity Read ↗

Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.Semantic proximity Read ↗

Gene of the month: <i>BECN1</i>Semantic proximity Read ↗

VPS34 stimulation of p62 phosphorylation for cancer progressionSemantic proximity Read ↗

<i>Atg6</i> is required for multiple vesicle trafficking pathways and hematopoiesis in <i>Drosophila</i>Semantic proximity Read ↗

TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced EndosomesSemantic proximity Read ↗

Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34Semantic proximity Read ↗

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.