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Article

Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades

27 Nov 2017

Abstract excerpt

Autophagy contributes to cellular homeostasis through the degradation of various intracellular targets such as proteins, organelles and microbes. This relates autophagy to various diseases such as infections, neurodegenerative diseases and cancer. A central component of the autophagy machinery is the class III phosphatidylinositol 3-kinase (PI3K-III) complex, which generates the signaling lipid...

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PMID: 29186924
DOI: 10.3390/ijms18122541

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