Article
A new class of errant DNA polymerases provides candidates for somatic hypermutation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001
Tippin B, Goodman M F
Abstract excerpt
The mechanism of somatic hypermutation of the immunoglobulin genes remains a mystery after nearly 30 years of intensive research in the field. While many clues to the process have been discovered in terms of the genetic elements required in the immunoglobulin genes, the key enzymatic players that mediate the introduction of mutations into the variable region are unknown. The recent wave of newly discovered...
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