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Article

Cyclooxygenase-2 polymorphisms and risk of systemic lupus erythematosus in Koreans.

Rheumatology international - 1 Nov 2006

Her Min-Young, El-Sohemy Ahmed, Cornelis Marilyn C, Kim Tae-Hwan, Bae Sang-Cheol

Abstract excerpt

Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity of systemic lupus erythematosus (SLE) in a Korean population. The study included 345 patients...

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PMID: 16871410
DOI: 10.1007/s00296-006-0162-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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