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Article

Association between COX-2 and 15-PGDH polymorphisms and SLE susceptibility.

International journal of rheumatic diseases - 1 May 2020

Sandoughi Mahnaz, Saravani Mohsen, Rokni Mohsen, Nora Mehrangiz, Mehrabani Mehrnaz, Dehghan Azizallah

Abstract excerpt

AIMS: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Prostaglandins E2 (PGE2), the product of the cyclo-oxygenase 2 (COX-2) enzyme, has critical roles in the etiology of autoimmune diseases. PGE2 level is controlled by a balance between its synthesis mediator (COX-2 enzyme) and its catabolic key enzyme (15-hydroxyprostaglandin dehydrogenase [15-PGDH] enzyme). In the present...

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PMID: 32100450
DOI: 10.1111/1756-185X.13808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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