Article
Matrix metalloproteinase-2 functional promoter polymorphism G1575A is associated with elevated circulatory MMP-2 levels and increased risk of cardiovascular disease in systemic lupus erythematosus patients.
Lupus - 1 May 2012
Bahrehmand F, Vaisi-Raygani A, Kiani A, Rahimi Z, Tavilani H, Navabi S J, Shakiba E, Hassanzadeh N, Pourmotabbed T
Abstract excerpt
Matrix metalloproteinase-2 (MMP-2) is a zinc dependent endonuclease that degrades type IV collagen, the major structural component of basement membranes. MMP-2 functional promoter polymorphism G1575A affects circulating level of MMP-2 and may be considered an important genetic determinant of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) patients. In this study, association between MMP-2 1575A...
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