DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.

doi:10.1073/pnas.0603682103

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Article

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2006

Durinovic-Belló Ivana, Rosinger Silke, Olson Jennifer A, Congia Mauro, Ahmad Regina C, Rickert Mathias, Hampl Johannes, Kalbacher Hubert, Drijfhout Jan W, Mellins Elizabeth D, Al Dahouk Sascha, Kamradt Thomas, Maeurer Markus J, Nhan Carol, Roep Bart O, Boehm Bernhard O, Polychronakos Constantin, Nepom Gerald T, Karges Wolfram, McDevitt Hugh O, Sønderstrup Grete

Abstract excerpt

Recently, we have identified proinsulin (P-Ins)(73-90) as an immunodominant T cell epitope of HLA-DRB1*0401 (DR4) subjects with beta-islet cell autoimmunity and of HLA-DR4/CD4 double-transgenic mice immunized with human P-Ins. We have compared the fine specificities of one human CD4 T cell clone and two mouse T cell hybridoma clones recognizing this epitope, and, although these three clones all recognized the...

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PMID: 16868084
DOI: 10.1073/pnas.0603682103
PMCID: PMC1544230

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