Humanized transgenic mice expressing HLA DR4-DQ3 haplotype: reconstitution of phenotype and HLA-restricted T-cell responses.

doi:10.1111/j.1399-0039.2006.00656.x

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Article

Humanized transgenic mice expressing HLA DR4-DQ3 haplotype: reconstitution of phenotype and HLA-restricted T-cell responses.

Tissue antigens - 1 Sept 2006

Chen Z, de Kauwe A L, Keech C, Wijburg O, Simpfendorfer K, Alexander W S, McCluskey J

Abstract excerpt

Many autoimmune conditions have close genetic linkages to particular human histocompatibility leukocyte antigen (HLA) class II genes. With the aim of establishing a murine model of autoimmune disease, we have generated an HLA DR4-DQ3 haplotype transgenic (Tg) mouse that expresses a 440-kb yeast artificial chromosome harbouring DRA, DRB1*040101, DRB4*010301, DQA1*030101, DQB1*0302 and all the internal regulatory...

Topics

Animals
Autoimmune Diseases
CD4-Positive T-Lymphocytes
Cell Line
Chromosomes, Artificial, Yeast
Disease Models, Animal
Genotype
HLA-DQ Antigens
HLA-DR4 Antigen
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Mice, Transgenic

Organ Specificity

Phenotype

Salmonella Infections

Salmonella typhimurium

Source

Open in PubMed

Identifiers

PMID: 16948641
DOI: 10.1111/j.1399-0039.2006.00656.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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