A multiple transgenic mouse model with a partially humanized activation pathway for helper T cell responses.

Abstract excerpt

Mice expressing human CD4 and human MHC II molecules provide a valuable model both for the investigation of the immunopathogenetic role of human autoantigens and for the development of therapeutic strategies based on modulating helper T cell activation in vivo. Here we present a novel mouse model expressing HLA-DR17 (a split antigen of HLA-DR3) together with human CD4 in the absence of murine cd4 (CD4/DR3 mice)....

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• Share to Antigen-Presenting Cells
• Share to CD4 Antigens