Article
Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997
Patel S D, Cope A P, Congia M, Chen T T, Kim E, Fugger L, Wherrett D, Sonderstrup-McDevitt G
Abstract excerpt
Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM is genetically associated with the major histocompatibility complex (MHC), and particular alleles from the HLA-DQ and HLA-DR loci contribu...
Topics
- Amino Acid Sequence
- Animals
- DNA, Complementary
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Epitope Mapping
- Genetic Predisposition to Disease
- Glutamate Decarboxylase
- HLA-DR Antigens
- Humans
- Immunodominant Epitopes
- Isoenzymes
- Mice