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Article

Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.

Journal of autoimmunity - 1 Aug 2009

Elagin Raya B, Balijepalli Sadguna, Diacovo Maria J, Baekkeskov Steinunn, Jaume Juan C

Abstract excerpt

MHC-class II genes determine susceptibility in human type-1 diabetes. In their context, presentation of target antigen(s) results in autoimmunity and beta-cell destruction. An animal model, in which human beta-cell autoantigen(s) are presented to effector cells in the context of human MHC-class II diabetes-susceptibility genes, would be desirable for studying molecular mechanisms of disease and developing...

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Source

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Identifiers

PMID: 19289270
DOI: 10.1016/j.jaut.2009.02.004
PMCID: PMC2705176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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