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Article

Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin.

Genes and immunity - 1 Mar 2010

Durinovic-Belló I, Wu R P, Gersuk V H, Sanda S, Shilling H G, Nepom G T

Abstract excerpt

Immune responses to autoantigens are in part controlled by deletion of autoreactive cells through genetically regulated selection mechanisms. We have directly analyzed peripheral CD4+ proinsulin (PI) 76-90 (SLQPLALEGSLQKRG)-specific T cells using soluble fluorescent major histocompatibility compl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20054344
DOI: 10.1038/gene.2009.108
PMCID: PMC2845516

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20054344-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin.PMID 20054344Read ↗

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Proinsulin is encoded by an RNA splice variant in human blood myeloid cells.Semantic proximity Read ↗

Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals.Semantic proximity Read ↗

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Semantic proximity Read ↗

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.Semantic proximity Read ↗

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