Article
Evolvability is a selectable trait.
Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2004
Earl David J, Deem Michael W
Abstract excerpt
Concomitant with the evolution of biological diversity must have been the evolution of mechanisms that facilitate evolution, because of the essentially infinite complexity of protein sequence space. We describe how evolvability can be an object of Darwinian selection, emphasizing the collective nature of the process. We quantify our theory with computer simulations of protein evolution. These simulations...
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