Selection enhances protein evolvability by increasing mutational robustness and foldability.

Abstract excerpt

Natural selection can promote or hinder a population's evolvability-the ability to evolve new and adaptive phenotypes-but the underlying mechanisms are poorly understood. To examine how the strength of selection affects evolvability, we subjected populations of yellow fluorescent protein to directed evolution under different selection regimes and then evolved them toward the new phenotype of green fluorescence....

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