Article
Non-adaptive complexity and biochemical function.
Current opinion in structural biology - 1 Apr 2022
Schulz Luca, Sendker Franziska L, Hochberg Georg K A
Abstract excerpt
Intricate biochemical structures are usually thought to be useful, because natural selection preserves them from degradation by a constant hail of destructive mutations. Biochemists therefore often deliberately disrupt them to understand how complexity improves protein function or fitness. However, evolutionary theory suggests that even useless complexity that never improved fitness can become completely...
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