Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein dynamism and evolvability.

Science (New York, N.Y.) - 10 Apr 2009

Tokuriki Nobuhiko, Tawfik Dan S

Abstract excerpt

The traditional view that proteins possess absolute functional specificity and a single, fixed structure conflicts with their marked ability to adapt and evolve new functions and structures. We consider an alternative, "avant-garde view" in which proteins are conformationally dynamic and exhibit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Evolution, Molecular
Share to Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutation

Share to Protein Conformation

Share to Protein Folding

Share to Proteins

Source

Identifiers

PMID: 19359577
DOI: 10.1126/science.1169375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19359577-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein dynamism and evolvability.PMID 19359577Read ↗

Stability effects of mutations and protein evolvability.Semantic proximity Read ↗

The Role of Conformational Dynamics and Allostery in Modulating Protein Evolution.Semantic proximity Read ↗

Mechanisms of protein evolution.Semantic proximity Read ↗

Natural history as a predictor of protein evolvability.Semantic proximity Read ↗

Simple mechanisms for the evolution of protein complexity.Semantic proximity Read ↗

The 'evolvability' of promiscuous protein functions.Semantic proximity Read ↗

Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustness.Semantic proximity Read ↗

A biological cosmos of parallel universes: does protein structural plasticity facilitate evolution?Semantic proximity Read ↗

Analysis of the relationships between evolvability, thermodynamics, and the functions of intrinsically disordered proteins/regions.Semantic proximity Read ↗

Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence.Semantic proximity Read ↗

What evolution tells us about protein physics, and protein physics tells us about evolution.Semantic proximity Read ↗

Conservation and coevolution determine evolvability of different classes of disordered residues in human intrinsically disordered proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.