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Article

How proteins adapt: lessons from directed evolution.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2009

Arnold F H

Abstract excerpt

Applying artificial selection to create new proteins has allowed us to explore fundamental processes of molecular evolution. These "directed evolution" experiments have shown that proteins can readily adapt to new functions or environments via simple adaptive walks involving small numbers of mutations. With the entire "fossil record" available for detailed study, these experiments have provided new insight into...

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Share to Adaptation, Biological
Share to Cytochrome P-450 Enzyme System
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADPH-Ferrihemoprotein Reductase

Share to Protein Stability

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Share to Recombination, Genetic

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Source

Identifiers

PMID: 20413708
DOI: 10.1101/sqb.2009.74.046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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