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Article

Tyk2 is dispensable for induction of myeloproliferative disease by mutant FLT3.

International journal of hematology - 1 Jul 2006

Nakajima Hideaki, Shibata Fumi, Kumagai Hidetoshi, Shimoda Kazuya, Kitamura Toshio

Abstract excerpt

Internal tandem duplication of FLT3 tyrosine kinase (FLT3-ITD) is the most prevalent mutation found in acute myelogenous leukemia (AML), having been identified in 20% to 30% of all AML patients. We have previously shown that FLT3-ITD signals mainly through the signal transducer and activator of transcription 5 (STAT5) pathway and have suggested the possible involvement of Tyk2 in STAT5 activation by FLT3-ITD. The...

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Topics

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Share to fms-Like Tyrosine Kinase 3
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Insertional

Share to Myeloproliferative Disorders

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Protein-Tyrosine Kinases

Share to STAT5 Transcription Factor

Share to TYK2 Kinase

Source

Identifiers

PMID: 16867903
DOI: 10.1532/IJH97.06016

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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