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Article

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

Molecular cell - 1 Sept 2000

Schwaller J, Parganas E, Wang D, Cain D, Aster J C, Williams I R, Lee C K, Gerthner R, Kitamura T, Frantsve J, Anastasiadou E, Loh M L, Levy D E, Ihle J N, Gilliland D G

Abstract excerpt

STAT5 is activated in a broad spectrum of human hematologic malignancies. We addressed whether STAT5 activation is necessary for the myelo- and lymphoproliferative disease induced by TEL/JAK2 using a genetic approach. Whereas mice transplanted with bone marrow transduced with retrovirus expressing TEL/JAK2 develop a rapidly fatal myelo- and lymphoproliferative syndrome, reconstitution with bone marrow derived...

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Source

Identifiers

PMID: 11030348
DOI: 10.1016/s1097-2765(00)00067-8

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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