The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.

doi:10.1007/BF00352328

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 1991

Moen C J, van der Valk M A, Snoek M, van Zutphen B F, von Deimling O, Hart A A, Demant P

Abstract excerpt

The development of tumors in mice is under multigenic control, but, in spite of considerable efforts, the identification of the genes involved has so far been unsuccessful, because of the insufficient resolution power of the available genetic tools. Therefore, a novel genetic tool, the RC (Recombinant Congenic) strains system, was designed. In this system, a series of RC strains is produced from two inbred...

Topics

1,2-Dimethylhydrazine
Animals
Biomarkers, Tumor
Carcinogenicity Tests
Colonic Neoplasms
DNA Probes
Dimethylhydrazines
Female
Genetic Predisposition to Disease
Isoantigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred BALB C

Polymorphism, Restriction Fragment Length

Recombination, Genetic

Sex Characteristics

Source

Open in PubMed

Identifiers

PMID: 1686571
DOI: 10.1007/BF00352328

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1686571-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.PMID 1686571Read ↗

Gene interaction and single gene effects in colon tumour susceptibility in mice.Semantic proximity Read ↗

Genetics of susceptibility to radiation-induced lymphomas, leukemias and lung tumors studied in recombinant congenic strains.Semantic proximity Read ↗

Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats.Semantic proximity Read ↗

Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse.Semantic proximity Read ↗

Opposite effects of modifiers of the ApcMin mutation in intestine and mammary gland.Semantic proximity Read ↗

Genetic control of susceptibility to carcinogen-induced colorectal cancer in mice: the Ccs3 and Ccs5 loci regulate different aspects of tumorigenesis.Semantic proximity Read ↗

Segregation of genes from donor strain during the production of recombinant congenic strains.Semantic proximity Read ↗

Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.Semantic proximity Read ↗

Recombinant congenic strains of mice: a new tool for the genetic dissection of efficacy and toxicity of adjuvants.Semantic proximity Read ↗

A two-locus system controls susceptibility to colitis-associated colon cancer in mice.Semantic proximity Read ↗

Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3.Semantic proximity Read ↗

Genetics of liver tumor susceptibility in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.