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Article

Segregation of genes from donor strain during the production of recombinant congenic strains.

Laboratory animals - 1 Jul 1991

van Zutphen L F, Den Bieman M, Lankhorst A, Demant P

Abstract excerpt

Recombinant congenic strains (RCS) constitute a set of inbred strains which are designed to dissect the genetic control of multigenic traits, such as tumour susceptibility or disease resistance. Each RCS contains a small fraction of the genome of a common donor strain, while the majority of genes stem from a common background strain. We tested at two stages of the inbreeding process in 20 RCS, derived from...

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PMID: 1921313
DOI: 10.1258/002367791780808329

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