Article
A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine - 15 Oct 2006
Takabatake Noriaki, Shibata Yoko, Abe Shuichi, Wada Toshihiro, Machiya Jun-ichi, Igarashi Akira, Tokairin Yoshikane, Ji Guijin, Sato Hidenori, Sata Makoto, Takeishi Yasuchika, Emi Mitsuru, Muramatsu Masaaki, Kubota Isao
Abstract excerpt
RATIONALE: Acute exacerbations (AEs) in chronic obstructive pulmonary disease (COPD) are a major cause of morbidity and mortality in COPD. OBJECTIVES: The marked heterogeneity in the host defense mechanisms may be attributed to single nucleotide polymorphisms (SNPs) in the inflammatory chemokines that show enhanced expression in the airway of patients with COPD who experience AEs. METHODS: We investigated four...
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