Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma.

Genes and immunity - 1 May 2005

Stemmler S, Arinir U, Klein W, Rohde G, Hoffjan S, Wirkus N, Reinitz-Rademacher K, Bufe A, Schultze-Werninghaus G, Epplen J T

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) and asthma are common complex diseases characterized by airflow obstruction and inflammatory processes in the small airways. lnterleukin 8 (IL-8) is a potent proinflammatory cytokine which interacts with the IL-8 receptor alpha (IL8RA, CXCR1) and beta (IL8RB, CXCR2), leading to activation and migration of leukocytes. In order to evaluate the role of the IL8RA gene in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Asthma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CXCR1 gene

Share to CXCR2 gene

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single-Stranded Conformational

Share to Pulmonary Disease, Chronic Obstructive

Share to Receptors, Interleukin-8A

Source

Identifiers

PMID: 15772681
DOI: 10.1038/sj.gene.6364181

Genes

CXCR1
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma.PMID 15772681Read ↗

Polymorphisms in the interleukin-8 gene in patients with chronic obstructive pulmonary disease.Semantic proximity Read ↗

Association of IL8, CXCR2 and TNF-α polymorphisms and airway diseaseSemantic proximity Read ↗

IL-8 gene variants are associated with lung function decline and multidimensional BODE index in COPD patients but not with disease susceptibility: a validation study.Semantic proximity Read ↗

Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts.Semantic proximity Read ↗

Impact of IL8 and IL8-Receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infectionsSemantic proximity Read ↗

The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease.Semantic proximity Read ↗

Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma.Semantic proximity Read ↗

The association of RAR-related orphan receptor A (RORA) gene polymorphisms with the risk of asthma.Semantic proximity Read ↗

IFN gamma and CXCR-1 gene polymorphisms in idiopathic bronchiectasis.Semantic proximity Read ↗

TNFA -308G>A in two international population-based cohorts and risk of asthma.Semantic proximity Read ↗

A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease.Semantic proximity Read ↗

Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.