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Article

IL-8 gene variants are associated with lung function decline and multidimensional BODE index in COPD patients but not with disease susceptibility: a validation study.

COPD - 1 Feb 2015

Córdoba-Lanús Elizabeth, Baz-Dávila Rebeca, Espinoza-Jiménez Adriana, Rodríguez-Pérez María C, Varo Nerea, de-Torres Juan P, González-Almeida Delia, Aguirre-Jaime Armando, Casanova Ciro

Abstract excerpt

BACKGROUND AND OBJECTIVE: COPD is a leading cause of dead worldwide and tobacco smoking is its major risk factor. IL8 is a proinflammatory chemokine mainly involved in the acute inflammatory reaction. The aim of this study was to test the association of IL-8, CXCR1 and CXCR2 gene variants and COPD susceptibility as part of a replication study and explore the effect of these variations in disease progression....

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Identifiers

PMID: 24946112
DOI: 10.3109/15412555.2014.908831

Genes

CXCR1
CXCR2
TNF

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