Article
SLC11A1 polymorphisms are associated with the risk of chronic obstructive pulmonary disease in a Korean population.
Biochemical genetics - 1 Aug 2008
Kim Eun Jin, Kim Kyung Mee, Park Sun Ha, Kim Jong Sik, Lee Won Kee, Cha Sung Ick, Kim Chang Ho, Kang Young Mo, Han Sung Beom, Jung Tae Hoon, Park Jae Yong
Abstract excerpt
The solute carrier family 11 member 1 (SLC11A1) protein plays important roles in macrophage activation and displays pleiotropic effects on various macrophage functions, including the regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and oxidative burst. Considering the important roles of macrophage in the pathogenesis of chronic obstructive pulmonary disease (COPD), we...
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