Article
HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.
Journal of neurovirology - 1 Aug 2016
Yasuma Keiko, Matsuzaki Toshio, Yamano Yoshihisa, Takashima Hiroshi, Matsuoka Masao, Saito Mineki
Abstract excerpt
Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, the risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) across lifetime differs between ethnic groups. There is an association between HTLV-1 tax gene subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. In this study, we investigated the full-length proviral genome...
Topics
- Adult
- Asian People
- Basic-Leucine Zipper Transcription Factors
- Female
- Forkhead Transcription Factors
- Gene Expression Regulation
- Gene Products, tax
- HTLV-I Infections
- Host-Pathogen Interactions
- Human T-lymphotropic virus 1
- Humans
- Leukocytes, Mononuclear