Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice.

doi:10.4049/jimmunol.170.4.1699

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Article

Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2003

Sun Jian, Matthias Gabriele, Mihatsch Michael J, Georgopoulos Katia, Matthias Patrick

Abstract excerpt

Here we show that mice lacking the zinc finger transcription factor Aiolos develop the symptoms of human systemic lupus erythematosus (SLE), which is characterized by the production of anti-dsDNA Ab and immune complex-mediated glomerulonephritis. This finding indicates that normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease and implicates...

Topics

Animals
Antibodies, Antinuclear
B-Lymphocytes
Bone Marrow Cells
Cell Differentiation
Cell Division
Cells, Cultured
Female
Germinal Center
Humans
Ikaros Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immune Complex Diseases

Immunoglobulins

Lupus Erythematosus, Systemic

Lymphocyte Activation

Male

Mice

Mice, Inbred C57BL

Source

Open in PubMed

Identifiers

PMID: 12574333
DOI: 10.4049/jimmunol.170.4.1699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice.PMID 12574333Read ↗

Aiolos regulates B cell activation and maturation to effector state.Semantic proximity Read ↗

Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1.Semantic proximity Read ↗

AIOLOS Variants Causing Immunodeficiency in Human and MiceSemantic proximity Read ↗

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Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domainsSemantic proximity Read ↗

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