Article
Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder.
Neuroscience letters - 20 Feb 2006
Nishiguchi Naoki, Breen Gerome, Russ Carsten, St Clair David, Collier David
Abstract excerpt
Glycogen synthase kinase-3beta (GSK3beta) is a target of lithium as well as sodium valproate, both of which are effective mood stabilizing prophylatics/treatments for bipolar disorder, a highly heritable psychiatric disorder. Though it is not clear whether the mood stabilizing effects of these drugs act directly through GSK3beta, it is a good candidate for mediating at least part of lithium's action, and is an...
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