Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Association between lithium sensitivity and GSK3beta gene polymorphisms in bipolar disorder].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology - 1 Jun 2012

Numajiri Maki, Aoki Jun, Iwahashi Kazuhiko, Fukamauchi Fumihiko, Enomoto Minoru, Yoshihara Eiji, Murayama Ohshi, Nishizawa Daisuke, Ikeda Kazutaka, Ishigooka Jun

Abstract excerpt

GSK-3beta codes for an enzyme which is a target for the action of mood stabilizers, lithium and possibly of valproic acid. The relationship between the polymorphisms (SNPs) of GSK-3beta-50T/C and -1727A/T and the effect of lithium was studied among 29 Japanese bipolar patients. It was shown that GSK-3beta-50T/C may be linked with the effect of lithium treatment. There is a significantly higher T-allele frequency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Lithium

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 22834106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Association between lithium sensitivity and GSK3beta gene polymorphisms in bipolar disorder].PMID 22834106Read ↗

[Evaluation of the Association between Lithium Treatment and GSK3β Polymorphism in Bipolar Disorder Patients].Semantic proximity Read ↗

Haplotype analysis of GSK-3β gene polymorphisms in bipolar disorder lithium responders and nonresponders.Semantic proximity Read ↗

Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium.Semantic proximity Read ↗

Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patients.Semantic proximity Read ↗

[The relationship between glycogen synthase kinase - 3beta -1727A/T x -50T/C genetic polymorphisms and nicotine dependence].Semantic proximity Read ↗

[Relationship between GSK-3 beta -50T/C and DBI +529A/T polymorphisms in Japanese alcoholics].Semantic proximity Read ↗

Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP.Semantic proximity Read ↗

Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder.Semantic proximity Read ↗

Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism.Semantic proximity Read ↗

No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population.Semantic proximity Read ↗

Meta-analysis demonstrates lack of association of the GSK3B -50C/T polymorphism with risk of bipolar disorder.Semantic proximity Read ↗

Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.