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Article

Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP.

Neuroscience letters - 7 Mar 2005

Benedetti Francesco, Serretti Alessandro, Pontiggia Adriana, Bernasconi Alessandro, Lorenzi Cristina, Colombo Cristina, Smeraldi Enrico

Abstract excerpt

The molecular mechanisms driving the biological clock in the suprachiasmatic nucleus of the hypothalamus may play a role in mood disorders. A single nucleotide polymorphism (SNP) (-50 T/C) falling into the effective promoter region (nt -171 to +29) of the gene coding for glycogen synthase kinase 3-beta (GSK3-beta) has been linked with different age at onset of bipolar illness and with different antidepressant...

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Identifiers

PMID: 15694273
DOI: 10.1016/j.neulet.2004.11.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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