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Article

Haplotype analysis of GSK-3β gene polymorphisms in bipolar disorder lithium responders and nonresponders.

Clinical neuropharmacology - 1 Jan 2000

Iwahashi Kazuhiko, Nishizawa Daisuke, Narita Shin, Numajiri Maki, Murayama Ohoshi, Yoshihara Eiji, Onozawa Yuuya, Nagahori Kenta, Fukamauchi Fumihiko, Ikeda Kazutaka, Ishigooka Jun

Abstract excerpt

The GSK-3β gene, GSK3B, codes for an enzyme that is a target for the action of mood stabilizers, lithium and possibly valproic acid.In this study, the relationship between haplotypes consisting of single nucleotide polymorphisms (SNPs) of GSK3B -50T/C and -1727A/T and the effect of lithium was studied among Japanese bipolar disorder lithium nonresponders and responders.The distributions of the GSK3B haplotypes...

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Identifiers

PMID: 24992082
DOI: 10.1097/WNF.0000000000000039
PMCID: PMC4206383

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Source receipt: pubmed, retrieved 7 Sept 2026.

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