Article
Fumarate is an essential intermediary metabolite produced by the procyclic Trypanosoma brucei.
The Journal of biological chemistry - 15 Sept 2006
Coustou Virginie, Biran Marc, Besteiro Sébastien, Rivière Loïc, Baltz Théo, Franconi Jean-Michel, Bringaud Frédéric
Abstract excerpt
The procyclic stage of Trypanosoma brucei, a parasitic protist responsible for sleeping sickness in humans, converts most of the consumed glucose into excreted succinate, by succinic fermentation. Succinate is produced by the glycosomal and mitochondrial NADH-dependent fumarate reductases, which are not essential for parasite viability. To further explore the role of the succinic fermentation pathways, we studied...
Topics
- Animals
- Cytosol
- Electrons
- Fumarates
- Glucose
- Green Fluorescent Proteins
- Microbodies
- Mitochondria
- Mutation
- Phylogeny
- Protein Isoforms
- RNA Interference
- Time Factors
- Trypanosoma brucei brucei