Article
ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma.
The Journal of biological chemistry - 18 May 2012
Millerioux Yoann, Morand Pauline, Biran Marc, Mazet Muriel, Moreau Patrick, Wargnies Marion, Ebikeme Charles, Deramchia Kamel, Gales Lara, Portais Jean-Charles, Boshart Michael, Franconi Jean-Michel, Bringaud Frédéric
Abstract excerpt
Insect stage trypanosomes use an "acetate shuttle" to transfer mitochondrial acetyl-CoA to the cytosol for the essential fatty acid biosynthesis. The mitochondrial acetate sources are acetate:succinate CoA-transferase (ASCT) and an unknown enzymatic activity. We have identified a gene encoding acetyl-CoA thioesterase (ACH) activity, which is shown to be the second acetate source. First, RNAi-mediated repression...
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