Back to search

Article

The bloodstream form of <i>Trypanosoma brucei</i> displays non-canonical gluconeogenesis

2023-04-06

Abstract excerpt

Trypanosoma brucei is a causative agent of the Human and Animal African Trypanosomiases. The mammalian stage parasites infect various tissues and organs including the bloodstream, central nervous system, skin, adipose tissue and lungs. They rely on ATP produced in glycolysis, consuming large amounts of glucose, which is readily available in the mammalian host. In addition to glucose, glycerol can also be used as a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
36585186-7bf0-5722-9f8b-2d985ba39b0f
DOI
10.1101/2023.04.06.535095
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The bloodstream form of <i>Trypanosoma brucei</i> displays non-canonical gluconeogenesisDOI 10.1101/2023.04.06.535095
Divergent metabolism between <i>Trypanosoma congolense</i> and <i>Trypanosoma brucei</i> results in differential drug sensitivitySemantic proximity
Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibitionSemantic proximity
Glycosomal phosphoenolpyruvate carboxykinase CRISPR/Cas9-deletion and its role in <i>Trypanosoma cruzi</i> metacyclogenesis and infectivity in mammalian hostSemantic proximity
Direct suppression of host gluconeogenesis by Trypanosoma bruceiSemantic proximity
Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditionsSemantic proximity
Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei.Semantic proximity
Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism.Semantic proximity
Dual metabolomic profiling uncovers <i>Toxoplasma</i> manipulation of the host metabolome and the discovery of a novel parasite metabolic capabilitySemantic proximity
A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite <i>Blastocystis</i>Semantic proximity
Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique featuresSemantic proximity
A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and VirulenceSemantic proximity
Extracellular glutamine is essential in cell division and flagellar function in bloodstream forms of <i>Trypanosoma brucei</i>Semantic proximity
Select a neighboring publication to make it the new centre.