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Article

Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme, NADH-dependent fumarate reductase.

The Journal of biological chemistry - 11 Oct 2002

Besteiro Sébastien, Biran Marc, Biteau Nicolas, Coustou Virginie, Baltz Théo, Canioni Paul, Bringaud Frédéric

Abstract excerpt

In all trypanosomatids, including Trypanosoma brucei, glycolysis takes place in peroxisome-like organelles called glycosomes. These are closed compartments wherein the energy and redox (NAD(+)/NADH) balances need to be maintained. We have characterized a T. brucei gene called FRDg encoding a protein 35% identical to Saccharomyces cerevisiae fumarate reductases. Microsequencing of FRDg purified from glycosome...

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PMID: 12138089
DOI: 10.1074/jbc.M201759200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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