Article

Perturbations in fumarate levels in <i>Plasmodium berghei</i> leads to cysteine succination and impairs ookinete formation

2026-03-16

Abstract excerpt

The TCA cycle intermediates comprise 8 carboxylic acids of which only fumarate has unsaturated carbons rendering it capable of electrophilic addition to cysteine thiols. Accumulation of fumarate due to loss of function of fumarate hydratase converts it into a powerful driver of cancer and therefore is classified as an oncometabolite. We have examined the consequences of perturbing the metabolism of fumarate and it...

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Literature Corpus work: ca7dd969-5d05-51aa-a631-73bf0c67783c
DOI: 10.64898/2026.03.16.711975

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Perturbations in fumarate levels in <i>Plasmodium berghei</i> leads to cysteine succination and impairs ookinete formationDOI 10.64898/2026.03.16.711975Read

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