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VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

5 Sept 2016

Abstract excerpt

The major human pathogen Mycobacterium tuberculosis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin-Antitoxin (TA) modules contribute to this persistence. Of these, 48 TA modules belong to the vapBC (virulence associated protein) gene family. VapC toxins are PIN domain endonucleases that, in enterobacteria, inhibit translation by site-specific cleavage of initiator...

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PMID: 27599842
DOI: 10.1093/nar/gkw781

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