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Article

Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Aug 2005

Maus Courtney E, Plikaytis Bonnie B, Shinnick Thomas M

Abstract excerpt

Capreomycin, kanamycin, amikacin, and viomycin are drugs that are used to treat multidrug-resistant tuberculosis. Each inhibits translation, and cross-resistance to them is a concern during therapy. A recent study revealed that mutation of the tlyA gene, encoding a putative rRNA methyltransferase, confers capreomycin and viomycin resistance in Mycobacterium tuberculosis bacteria. Mutations in the 16S rRNA gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Ribosomal, 16S

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Identifiers

PMID: 16048924
DOI: 10.1128/AAC.49.8.3192-3197.2005
PMCID: PMC1196259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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