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Differential recruitment of DNA Ligase I and III to DNA repair sites

19 Jul 2006

Abstract excerpt

DNA ligation is an essential step in DNA replication, repair and recombination. Mammalian cells contain three DNA Ligases that are not interchangeable although they use the same catalytic reaction mechanism. To compare the recruitment of the three eukaryotic DNA Ligases to repair sites in vivo we introduced DNA lesions in human cells by laser microirradiation. Time lapse microscopy of fluorescently tagged...

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PMID: 16855289
DOI: 10.1093/nar/gkl492

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