Article
Human DNA ligase I efficiently seals nicks in nucleosomes.
The EMBO journal - 16 Oct 2000
Chafin D R, Vitolo J M, Henricksen L A, Bambara R A, Hayes J J
Abstract excerpt
The access to DNA within nucleosomes is greatly restricted for most enzymes and trans-acting factors that bind DNA. We report here that human DNA ligase I, which carries out the final step of Okazaki fragment processing and of many DNA repair pathways, can access DNA that is wrapped about the surface of a nucleosome in vitro and carry out its enzymatic function with high efficiency. In addition, we find that...
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