Article
Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2006
Wang Tian, Gao Yunfei, Scully Eileen, Davis C Todd, Anderson John F, Welte Thomas, Ledizet Michel, Koski Raymond, Madri Joseph A, Barrett Alan, Yin Zhinan, Craft Joseph, Fikrig Erol
Abstract excerpt
West Nile (WN) virus causes fatal meningoencephalitis in laboratory mice, and gammadelta T cells are involved in the protective immune response against viral challenge. We have now examined whether gammadelta T cells contribute to the development of adaptive immune responses that help control WN virus infection. Approximately 15% of TCRdelta(-/-) mice survived primary infection with WN virus compared with 80-85%...
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