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CD8<sup>+</sup>T Cells Require Perforin To Clear West Nile Virus from Infected Neurons

13 Dec 2005

Abstract excerpt

Injury to neurons after West Nile virus (WNV) infection is believed to occur because of viral and host immune-mediated effects. Previously, we demonstrated that CD8+ T cells are required for the resolution of WNV infection in the central nervous system (CNS). CD8+ T cells can control infection by producing antiviral cytokines (e.g., gamma interferon or tumor necrosis factor alpha) or by triggering death of...

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PMID: 16352536
DOI: 10.1128/jvi.80.1.119-129.2006

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