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Article

Regulatory T Cells Shape the Resident Memory T Cell Response to Virus Infection in the Tissues

11 Dec 2013

Abstract excerpt

Regulatory T cells (Tregs) are well known for their role in dampening the immune responses to self-Ags and, thereby, limiting autoimmunity. However, they also must permit immune responses to occur against foreign infectious agents. Using a mouse model of West Nile virus infection, we examined the role of Tregs in the generation of effector and memory T cell responses in the secondary lymphoid organs, as well as...

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PMID: 24337378
DOI: 10.4049/jimmunol.1202153

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