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Article

A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways.

Vaccine - 28 Aug 2013

Xie Guorui, Welte Thomas, Wang Jia, Whiteman Melissa C, Wicker Jason A, Saxena Vandana, Cong Yingzi, Barrett Alan D T, Wang Tian

Abstract excerpt

Prior work shows that an attenuated West Nile virus (WNV), the nonstructural (NS)4B-P38G mutant infection in mice induced strong immune responses and protected host from subsequent lethal wild-type WNV infection. Here, we investigated NS4B-P38G mutant infection in myeloid differentiation factor 88-deficient (MyD88(-/-)) and Toll-like receptor 7-deficient (TLR7(-/-)) mice and found they had enhanced susceptibility...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23845800
DOI: 10.1016/j.vaccine.2013.06.093
PMCID: PMC3870894

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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