Article
Seizure susceptibility and epileptogenesis in a rat model of epilepsy and depression co-morbidity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2012
Epps S Alisha, Tabb Kroshona D, Lin Sharon J, Kahn Alexa B, Javors Martin A, Boss-Williams Katherine A, Weiss Jay M, Weinshenker David
Abstract excerpt
Although a strong co-morbidity exists clinically between epilepsy and depression, the cause of this co-morbidity remains unknown, and a valid animal model is crucial for the identification of underlying mechanisms and the development of a screening tool for novel therapies. Although some rodent models of epilepsy have been reported to display behaviors relevant to affective disorders, the seizure susceptibility...
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