Article
Determination of NAT2 acetylation status in the Greenlandic population.
Archives of toxicology - 1 Apr 2016
Geller Frank, Soborg Bolette, Koch Anders, Michelsen Sascha Wilk, Bjorn-Mortensen Karen, Carstensen Lisbeth, Birch Emilie, Nordholm Anne Christine, Johansen Marie Mila Broby, Børresen Malene Landbo, Feenstra Bjarke, Melbye Mads
Abstract excerpt
N-acetyltransferase 2 (NAT2) is a well-studied phase II xenobiotic metabolizing enzyme relevant in drug metabolism and cancerogenesis. NAT2 activity is largely determined by genetic polymorphisms in the coding region of the corresponding gene. We investigated NAT2 acetylation status in 1556 individuals from Greenland based on four different single nucleotide polymorphism (SNP) panels and the tagging SNP...
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